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  • Genomic Testing Options & Pricing
  • 2017 Genomic Release Schedule
  • Genetic Codes & Conditions
  • Reference Information
  • Enlight
Holstein Association USA Genomic Testing Options & Pricing

Holstein Association USA offers a wide array of genetic testing options to meet your needs. Order your genomic or genetic testing kits today by calling Customer Service at 800.952.5200, or email genomics@holstein.com.

 

        

        


Genomic Testing Options
Updated March 1, 2016
       
U.S. Customers Regular Enlight® Holstein COMPLETE® COMPLETE + Enlight
CLARIFIDE® Low-Density SNP Test $46 $42.50 $43.70 $39.50
CLARIFIDE Plus® Low-Density SNP Test + Dairy Wellness Traits* n/a $50 n/a $46
CLARIFIDE Ultra® High-Density SNP Test $125 $86 $118.75 $79
CLARIFIDE Ultra Plus® High-Density SNP Test + Dairy Wellness Traits* n/a $86 n/a $79
Wellness Trait Upgrade for Previously CLARIFIDE-Tested Animals n/a $10 n/a $8
Wellness Trait Upgrade for Previously Genomic Tested (Non-CLARIFIDE) Animals
**Requires new DNA sample to be submitted to lab
n/a $38 n/a $35

*CLARIFIDE Plus products which include Dairy Wellness Traits may only be ordered through Enlight®. Click here to learn more about the CLARIFIDE Plus products.
CLARIFIDE® is a registered trademark of Zoetis LLC.
 

International Customers Price      
Geneseek® Genomic Profiler Bovine 30K (GGP-LD) $58*      
Geneseek® Genomic Profiler Ultra High-Density Bovine 150K (GGP-HD) $135*      
*Plus Foreign Basic ID fee of $10 or registration fee
GeneSeek® is a registered trademark of Neogen Corporation.

The Council on Dairy Cattle Breeding (CDCB) may assess additional evaluation fees on top of the cost of the genomic test, dependent on the amount and type of data a dairy producer is contributing to the U.S. national genetic evaluation system. In general, most Holstein COMPLETE herds will qualify for Total Program pricing, which is $0 additional for females, and $15 additional fee for males, billed at the time the genomic test is ordered. Click here to learn more about Council on Dairy Cattle Breeding fees.

Additional Genetic Testing

Official Genetic Conditions Ordered with
Genomic Test
Ordered Separate
from a Genomic Test
Brachyspina $30 $45
BLAD (Bovine Leukocyte Adhesion Deficiency) Included $25
Coat Color (Recessive Red & Dominant Red) Included $25
CVM (Complex Vertebral Malformation) $40 $40
DUMPS (Deficiency of Uridine Monophosphate Synthase) Included Call for details
Mulefoot Haplotype Provided $150
Polled/Horned $40 $50
Milk Proteins Ordered with
Genomic Test
Ordered Separate
from a Genomic Test
Beta Casein A2 $20 $22
Beta Lactoglobulin Included $35
Kappa Casein Included $35
Other Testing Ordered with
Genomic Test
Ordered Separate
from a Genomic Test
Citrullinemia Included Call for details
Factor XI Included $40
Freemartin Testing (requires blood sample) Call for details Call for details

For more information about genetic conditions click here.

Parentage Testing Services

Holstein USA offers parentage verification services for the many needs that may arise on a dairy farm, including bulls, dams of bulls, donor dams, embryo transfer calves and parentage determination when ID questions arise. To learn more about your options and decide which test is right for your situation, contact the Quality Assurance department.

SNP Parentage Verification $46      
Microsattelite Parentage Testing $45      
Learn more in this Holstein Pulse article, "Demystifying Parentage Verification Requirements"
 

Other Services

Embryo Export Certificates, with related genotypes $30    
Special Export Documents including Recessive Statements $20    
2017 Genomic Release Schedule

When you genomic test your animals through Holstein Association USA, you will receive two sets of results back for each animal.

Preliminary (Weekly) Genomic Evaluations are delivered three to four weeks after a sample is sent to the lab. These predictions are not to be used for merchandising purposes. New preliminary genomic evaluations are distributed every Tuesday morning via e-mail and in Enlight®.

Interim Monthly Genomic Evaluations are delivered on a schedule established by the laboratories and the Council on Dairy Cattle Breeding (CDCB). Refer to the chart below for deadlines to receive an interim genomic prediction.

Official Genetic Evaluations are published three times per year, in April, August and December. Official genetic evaluations are published on pedigrees and other Holstein Association USA performance products.

2017 Interim Genomic Evaluation Release Schedule

Sample Deadline
Individual Predictions Available**
December 1, 2016 January 3, 2017
January 1 February 7
February 1 March 7
March 1 April 4**
April 1 May 2
May 1 June 6
June 1 July 5
July 1 August 8**
August 1 September 5
September 1 October 3
October 1 November 7
November 1 December 5**
**Denotes a genomic release that coincides with an official genetic evaluation.

Sample Deadline - This is the date that customers should have samples to testing laboratories.

Genomic Predictions Published - This is the day we expect to have individual genomic predictions available at www.holsteinusa.com, and on Enlight (www.enlightdairy.com). Reports are also distributed to customers via email or postal mail.

*Please note that date results will be available is an estimated date.
  Information is subject to change. Please refer to
  https://www.uscdcb.com/reference/sched.htm for any updates to the evaluation schedule.


   
Genetic Conditions in the Holstein Breed
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Holstein Association USA recognizes the importance of identifying heritable, sometimes undesirable, unique genes in Holstein cattle, to provide breeders with the tools they need to make informed breeding decisions. Use the free tools below to learn more about genetic testing and research animals to see if they have been tested as carriers or non-carriers for various traits, or may potentially be a carrier based on their pedigree. For more information, call Holstein Association USA customer service at 800.952.5200.

Holstein Haplotype Associated with Cholesterol Deficiency (HCD)
 

The DNA of an animal is transmitted to the next generation as a long sequence of chemical bases (A, C, G and T). These chemical bases, are often referred to as SNPs, and are grouped (linked) together on chromosomes. Genomic testing allows us to track each section of a chromosome by following a specific set of SNPs. A haplotype is a combination of alleles (DNA sequences) at different locations on a chromosome that are transmitted together as a group (linked).

German researchers discovered and reported on a new deleterious haplotype in Holsteins, causing young calves to die if homozygous, at the July 2015 Interbull meeting. Researchers have concluded that heterozygous animals have reduced cholesterol, but homozygotes have no cholesterol and survive only a few months.

Since the genetic variant causing this genetic defect is relatively new, the haplotype carrying the defect is difficult to track because both the normal version and the defected version occur frequently, especially in Canadian Holsteins. The two haplotype versions look identical when examining only the surrounding marker genotypes. Pedigree information, in combination of having knowledge of the haplotype status of earlier ancestors, allows for an accurate determination. A direct gene test is expected to be available soon.

Codes of 0 to 4 are being used to denote an animal’s haplotype status.

Haplotype Code Description
0 Non-carrier: free of HCD
1 Carrier: haplotype confirmed with pedigree information
2 Homozygous: confirmed on both sides of pedigree
3 Suspect carrier: haplotype origin could not be confirmed from pedigree
4 Suspect homozygous: probable carrier and may be homozygous; origin of haplotypes could not be confirmed from pedigree

For more information on HCD, read "Holstein Haplotype for Cholesterol Deficiency (HCD)"
by Paul VanRaden and Dan Null, USDA-AGIL

Holstein Association USA encourages breeders to pay attention to pedigrees, work to learn the status of their animals, be mindful of the status of service sires in their herd, and avoid mating carriers of individual deleterious haplotypes to carriers of the same haplotype. Discovery and labelling of these haplotypes is a benefit of genomic testing, and gives breeders the opportunity to improve the genetic quality of the breed through careful mating.

HCD results will be available for all animals who have been previously genomic tested. The lists below contain information on the HCD status of tested animals. This information may also be found using the Family Tree Search, and breeders may view the status of tested animals in their own herds using Enlight®.

HCD results will be available for all animals who have been previously genomic tested. This information may also be found using the Family Tree Search, and breeders may view the status of tested animals in their own herds using Enlight®, or see the lists below on this page - Tested Bull Haplotype Status and Tested Female Haplotype Status.

Haplotypes Impacting Fertility
 

Dairy researchers have discovered five haplotypes impacting fertility; referred to as HH1, HH2, HH3, HH4 and HH5, these haplotypes are believed to cause embryonic or fetal death when present in homozygous form, i.e., the offspring inherits the haplotype from both the sire and dam. In a herd, this would appear as if a cow did not conceive, resulting in greater days open and lower conception rates. Researchers have found that these haplotypes never occur in homozygous form amongst any living animal (that had their genome tested; the group researchers studied). That scenario is highly unlikely based on population probabilities, unless affected animals did not survive to birth.

Holstein Association USA encourages breeders to pay attention to pedigrees, work to learn the status of their animals, be mindful of the status of service sires in their herd, and avoid mating carriers of individual haplotypes to carriers of the same haplotype. It is possible for fertility rates to be improved by carefully selecting matings to avoid the chance of potential offspring inheriting the lethal version of a haplotype impacting fertility. Discovery and labelling of these haplotypes is a benefit of genomic testing, and gives breeders the opportunity to improve the genetic quality of the breed through careful mating.

Use the Family Tree Search to view haplotype status of individual animals.

A complete list of all animals that are known carriers or tested non-carriers of these undesirable haplotypes, at this time, can be found below.

All animals are listed alphabetically by name; animals with a number as the start of their prefix will be listed under "Numeric." A list of all males and females that have been identified as carriers is available beneath the general listings for quick reference.

Tested Bull Haplotype Status (pdf pdf format)
Numeric & A G M T  
B H N U
C I O V
D J P & Q W
E K R X, Y & Z
F L S  
List of all carrier bulls
 
Tested Female Haplotype Status (pdf pdf format)
Numeric & A G M T
B H N U
C I O V
D J P & Q W
E K R X, Y & Z
F L S  
List of all carrier females

Brachyspina
  The Holstein Association USA board of directors voted at their March 2011 meeting to label Brachyspina as an undesirable recessive trait in the Holstein breed.

Answers to Frequently Asked Questions about Brachyspina (pdf)



Using the Free Family Tree Search to Research Lineage
  Use the family tree search to find information about animals and their ancestors. For each animal in the family tree, among other information, it will show any genetic codes as well as any available haplotypes that have been recorded. Official genetic codes are also available on Official Holstein PedigreesTM and in the Holstein Association USA Sire Summaries. Click below to be taken to the Family Tree Search page. Alternatively, clicking on any animal's registration number from the Animal Search results page will pull up their family tree.

Use this tool to:
  • Identify bulls or cows recorded as carriers/non-carriers for genetic conditions and haplotypes
  • Find individuals that have not been tested but may be carriers for a gene.
  • Research ancestry on your animals to be sure you are aware of any possible concerns for genetic recessives that may be transmitted before making breeding decisions.
  • Identify animals in your herd that you may want to genetic test, based on their lineage and haplotype status.

Click here to go to the Family Tree Search
 
      Click here to view an example of tracing recessive traits in a family tree


What do all of the codes mean?
  Use the key below to translate the meaning of the various genetic testing codes.

GENETIC CODES
BD Bulldog*      
BL Bovine Leukocyte Adhesion Deficiency (BLAD)*    PO Observed Polled**
TL Tested free of BLAD   PC Tested Heterozygous Polled**
BY Brachyspina*   PP Tested Homozygous Polled**
TY Tested free of Brachyspina   TP Tested free of the Polled Condition (horned)
CV Complex Vertebral Malformation (CVM)*   PT Pink Tooth (Porphyria)*
TV Tested free of CVM   RC Carrier for red hair color*
DP Deficiency of Uridine Monophosphate Synthase (DUMPS)*   B/R Black/Red hair color*
TD Tested free of DUMPS   TR Tested free to red hair color
MF   Mulefoot*   DR1 Tested Heterozygous for
Dominant Red*
TM Tested free of Mulefoot   DR2 Tested Homozygous for
Dominant Red**
         
         

*Recessive gene carrier          **Dominant gene carrier

How are these conditions inherited?

Recessive genes are expressed only when a carrier cow is mated to a carrier bull. In a random mating population, when two carriers are mated, 50% of the resulting offspring will be carriers of the recessive alleles (heterozygous), 25% will express the recessive trait (homozygous recessive alleles), and 25% will not carry the recessive alleles (homozygous dominant alleles). When a non-carrier is mated to a carrier, it can be expected that 50% of the resulting calves will be carriers (heterozygous) and 50% will be non-carriers (homozygous for the dominant alleles).

EXAMPLE: Two RC animals, carriers for red hair color are mated. (Rr x Rr)


25% Black and White, non-RC (RR)
50% Black and White, Red Carrier (Rr)
25% Red and White

Dominant genes are expressed anytime an allele is present, whether it is heterozygous or homozygous. For example, if you have a cow that is heterozygous Polled (tested-PC), and she is mated to a non-polled bull, it can be expected that 50% of the resulting calves will be polled (heterozygous carriers) and 50% will not be polled (and homozygous for the non-polled alleles). If you have a cow that is homozygous Polled (PP), mated to a non-polled bull, all of the calves will be polled, heterozygous carriers.

EXAMPLE: A heterozygous polled bull (Hh) is mated to a non-polled cow(hh)


50% heterozygous polled (no horns, Hh)
50% horned (hh)


Reference Information

TSUTissue Sample Units (TSUs)
Tissue sampling units (TSUs) are a method of submitting DNA for genetic testing. Many dairymen find it a more convenient sample to collect than taking a hair or blood sample, and it typically has more reliable sample quality than hair. We offer several TSU options to meet your dairy’s needs.

Order your TSUs today!
Call 800.952.5200, or email genomics@holstein.com

  Box of 10 TSUs $25
  Box of 100 TSUs $240
  TSU Applicator $50*
*Customers purchasing at least 100 TSUs (10 boxes of 10) for their first order will receive a free TSU applicator, limit one per customer. It is not recommended to purchase more than one year’s worth of TSUs at a time.

TSU + Official Holstein Tag Combos
Customers testing most of the heifers born on their farm may be interested in our TSU + Official Holstein Tag combs, which provide a TSU in a nested pair with your choice of several official Holstein ear tags.

840 Tissue Sampling Unit (TSU) + Tag Combos
1-49 50-99 100-499 500-1999 2000+
Mini Round + TSU $3.15 $3.15 $3.10 $3.10 $3.10
Mini Round & Maxi + TSU $4.80 $4.70 $4.55 $4.45 $4.35
Mini Round & Custom Maxi + TSU $5.00 $4.90 $4.65 $4.50 $4.40
RFID + TSU $4.95 $4.85 $4.75 $4.65 $4.50
RFID & Maxi + TSU $6.60 $6.40 $6.20 $6.00 $5.75
RFID & Custom Maxi + TSU $6.80 $6.60 $6.30 $6.05 $5.80
Maxi + TSU $4.15 $4.05 $3.95 $3.85 $3.75
The Tag/TSU combo option is printed with your Herd Management Number (HMID) on the TSU tube and the HMID as the visible identification number on your tag

Streamline your animal identification and genomic testing with TSUs and Enlight®!
Producers using TSUs and Enlight to identify their calves and ordering genomic testing materials can streamline their sample submission process and skip the genomic test paperwork by providing TSU numbers at the time of ID and test ordering. Contact Holstein Association USA’s EASY Support Line (ext. 4205) for more information on that convenient option.

Council on Dairy Cattle Breeding (CDCB ) Fee Schedule for Genomic Evaluations

The following fees are required by the CDCB and apply to all animals being submitted for genomic testing. These fees are in addition to the base cost of ordering a genomic test for an animal. The fee schedule encourages contributors to not only maintain but grow the amount of information and kinds of data they are contributing to the system to improve genomic estimates in the future. The CDCB board approved the fees in the following table at their February 04, 2015 board meeting. The fee schedule linked below is updated as of March 2, 2015.

After each official genetic evaluation (in April, August and December), herds will qualify for a rate code 1, 2 or 3, based on the herd's previous contribution to the cooperator database. A rate code of 1 is available to a submitter whose animals have supplied the most valuable and quality data into the cooperator database; a rate code of 3 indicates there is limited contribution of data to the cooperator database. The rate code assignments will take effect on the release date of the official genetic evaluation.

All required Female Fees and Initial Male Fees will be collected by the nominator (Holstein Association USA, in this case). AI Service Fees will be collected by NAAB. All fees collected will be forwarded to CDCB. The Female Fee and Initial Male Fee will be charged only on the first genotype submitted for that animal. There will be no refund of fees, even if the genomic test results do not work to the submitter's satisfaction, or a male is not placed into service.

The following fees are in addition to lab and nominator fees
(Updated March 2, 2015)

Rate Code Kind of Participation Female Fee Initial Male Fee AI Service Fee for Males
1 Total Program None $15 $575
2 Member $1 $22 $575
3 Non-Member $3 $150 $575
4 Canada $6 $150 $575
5 Approved Partners $7 $15 $575
6 All Others $7 $150 $1,200

Total Program: In general, most Holstein COMPLETE herds will qualify for Total Program pricing. Eligibility for Total Program pricing requires the animal or its dam to be in a DHI herd that has contributed to the cooperator database with at least 50% (or 100 animals) of the eligible first lactation animals calving in the prior 14 months receive official cow evaluations for milk yield and have at least 4 animals classified in the previous 16 months, that contribute to the breed association's type evaluations.

Member: Member pricing requires the animal or its dam to be in a DHI herd that has contributed to the cooperator database with at least 20% (or 50 animals) of the eligible first lactation animals calving in the prior 14 months receive official cow evaluations for milk yield. Herds that do not contribute production data to the cooperator database, but who classified all required first lactation females in the herd at least once in the 16-months prior to the latest genetic evaluation may also qualify for Member rates.

Non-Member: Non-Member rates will be charged for animals in U.S. herds that do not qualify for the Total Program or Member rates.

For more information about which rate your animals are eligible for, or how to sign up for Holstein COMPLETE to receive Total Program rates, contact Holstein Association USA Customer Service at 800.952.5200. More detailed information about the various categories, rate codes, and stipulations for each is provided in the below linked document from the Council on Dairy Cattle Breeding.

CLICK HERE TO VIEW THE PDF OF THE FEE SCHEDULE AND COMPLETE FOOTNOTES,
AS PUBLISHED BY THE CDCB
(Fees updated March 2, 2015)

Enlight® Holstein Genetic Management Resource
Illuminating your herd’s genetic potential

Enlight® is an online, comprehensive management tool designed to help Holstein breeders more efficiently manage herd genetics. Through Enlight, dairy producers have unprecedented access to powerful reporting and analytics, including:

  • Youngstock, whole-herd and individual animal reports
  • Updated genetic and genomic information available the day it is released
  • Benchmarking tools
  • Interactive graphs
  • Access to a comprehensive list of production, health and type traits and associated indexes for all animals in their herds.

Site navigation is simple and straightforward, and convenient how-to videos help producers quickly put their data to work.

This exciting and valuable resource is a collaboration between Holstein Association USA and Zoetis, bringing together the strengths of both organizations to create a powerful resource to benefit all Holstein dairy producers. Once enrolled in Enlight, all tests ordered by a herd will be processed by Zoetis, using one of their CLARIFIDE test options.


 

 

Enroll today!
800.952.5200
www.enlightdairy.com

 

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